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Sionna Therapeutics Inc
21 Hickory Drive, Suite 500
Phone: (617) 819-2020p:617 819-2020 WALTHAM, MA  02451  United States Ticker: SIONSION
Business Summary
Sionna Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on researching and developing novel medicines for cystic fibrosis. It is advancing a pipeline of small molecules engineered to correct the defects caused by the F508del genetic mutation, which resides in nucleotide-binding domain 1 (NBD1). It is conducting ongoing Phase I trials of its two highly potent NBD1 stabilizers, SION-719 and SION-451, evaluating the safety, tolerability and pharmacokinetic (PK) profile of single and multiple ascending doses in healthy subjects. It is also developing a portfolio of cystic fibrosis transmembrane conductance regulator (CFTR) modulators designed to work synergistically with its NBD1 stabilizers to improve CFTR function. Its portfolio also includes Galicaftor (SION-2222) and SION-2851, which are TMD1-directed CFTR correctors; SION-109, an ICL4-directed CFTR corrector, and Navocaftor (SION-3067), is a clinical-stage potentiator of CFTR gating activity.

Scores and Ratings
FRISK®
Score		 Z''
Score		 PAYCE®
Score		 DBT
Index		 Moody's
Rating		 Fitch
Rating		 DBRS
Rating
YesYes-Yes---

Financials, News and Filings
Latest
Statement		 Last
Audit
News		 SEC
Filings		 Bankruptcy
Filings		 Suit &
Judgment
Filings		 Tax
Lien
Filings
9/30/202412/31/2023YesYes---

Industries
SIC Code Description
2834 Pharmaceutical preparations
8731 Commercial physical and biological research

Officers and Directors

Title
Name
Age		 Title
Date		 Start
Date
Independent Chairman of the Board of Director PaulClancy 63 6/1/2022 6/1/2022
President, Chief Executive Officer, Director MichaelCloonan 53 5/1/2021 5/1/2021
Chief Financial Officer, Head - Corporate Development Elena H.Ridloff 45 9/1/2021 9/1/2021
5 additional Officers and Directors records available in full report.

Business Names
Business Name
SION
SIONNA THERAPEUTICS
Sionna Therapeutics Securities Corporation

General Information
Number of Employees: 28 (As of 12/31/2023)
Outstanding Shares: 42,520,700 (As of 2/7/2025)
Stock Exchange: NASD
Fax Number: (302) 655-5049


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Friday, February 21, 2025