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Prime Medicine, Inc
60 First St.
Phone: (302) 658-7581p:302 658-7581 CAMBRIDGE, MA  02141  United States Ticker: PRMEPRME
Business Summary
Prime Medicine, Inc. is a biotechnology company focused on developing genetic medicines designed to provide durable, and potentially curative, treatment options for patients with diseases driven by defined genetic alterations, acquired cellular dysfunction, or dysregulated gene expression. Its gene editing technology enables targeted modifications to genomic deoxyribonucleic acid (DNA) without introducing double-stranded breaks. The Company pipeline includes wholly owned in vivo programs targeting liver genetic diseases Wilson Disease, Alpha-1 Antitrypsin Deficiency (AATD) as well as early-stage discovery efforts in Cystic Fibrosis (CF). The PM359 is an ex vivo prime editing program designed to correct the GT mutation in the NCF1 gene, the most common cause of Chronic Granulomatous Disease (CGD). This program provides validation of prime editing in human cells. The Wilson Disease is a rare autosomal recessive disorder caused by loss-of-function mutations in ATP7B.
(Source: 6-K)

Scores and Ratings
FRISK®
Score		 Z''
Score		 PAYCE®
Score		 DBT
Index		 Moody's
Rating		 Fitch
Rating		 DBRS
Rating
YesYes-Yes---

Financials, News and Filings
Latest
Statement		 Last
Audit
News		 SEC
Filings		 Bankruptcy
Filings		 Suit &
Judgment
Filings		 Tax
Lien
Filings
3/31/202612/31/2025YesYes---

Industries
SIC Code Description
8731 Commercial physical and biological research
2836 Biological products, except diagnostic substances

Officers and Directors

Title
Name
Age		 Title
Date		 Start
Date
Executive Chairman of the Board JeffreyMarrazzo 46 5/19/2025 5/10/2023
Chief Executive Officer, Director AllanReine 50 4/16/2026 1/17/2024
Co-Founder, Head of Prime Editing Platform AndrewAnzalone 38 1/1/2022 8/1/2020
9 additional Officers and Directors records available in full report.

Business Names
Business Name
Prime Medicine Massachusetts Securities Corp.
Prime Medicine Securities Corp.
PRME

General Information
Number of Employees: 146 (As of 12/31/2025)
Outstanding Shares: 180,617,451 (As of 4/30/2026)
Shareholders: 14
Stock Exchange: NASD
Federal Tax Id: 843097762
Fax Number: (302) 655-5049


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Tuesday, May 12, 2026